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Pyrotinib has favorable drug-like physicochemical properties and shows relatively higher oral exposure in human subjects with a much longer half life than that of preclinical animal species such as mouse
Solubility: DMSO : < 1 mg/mL (insoluble or slightly soluble)
Smiles: O=C(NC1=CC(=CC=C1)C(F)(F)F)NC1C=CC(=CC=1)NC1=NC(=CC=N1)NC1C=C(NN=1)C1CCCC1
InChiKey: QGBRLVONZXHAKJ-UHFFFAOYSA-N
BIBU 1361 dihydrochloride Catalog No.:M21988-C Pyrotinib has favorable drug-like physicochemicalBIBU 1361 dihydrochloride is a selective inhibitor of epidermal growth factor receptor (EGFR) kinase with an IC50 value of 0. 038 0. 007 M [1, 2]. The EGFR signaling pathway is associated with multiple intracellular signaling events that promote proliferation and survival. It plays a key role in the progression of glioblastoma multiforme (GBM) . In glioma cells, EGFR signaling can induce the phosphorylation of Akt, Erk1 2 and STAT3. BIBU 1361
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